post finasteride syndrome myth

Indeed, delineating the pathophysiological mechanisms underlying PFS will be of paramount importance to the understanding of this syndrome and to development of potential novel therapeutic modalities. Then they have no ejaculate. It shows a much higher signal in comparison with other drugs used for alopecia or suspected to affect mood Im surprised the FDA has not done these simple comparisons to explore safety signals for finasteride. My hypothesis is that finasteride can cause brain damage which needs to be reversed. Discover, October 2020. Post finasteride syndrome is so real! PMC An observational retrospective evaluation of 79 young men with longterm adverse effects after use of finasteride against androgenetic alopecia: Androlog, Jan. 13, 2016. However, cognitive functions, depression, and quality of life were not improved. Clipboard, Search History, and several other advanced features are temporarily unavailable. After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. You do think that these hypothetical damages can be reversed ? Brain fog ). Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. I have patients ask about [finasteride] all the time and I always discuss the risks of sexual dysfunction at length but its amazing how many guys seem not to care. Post-Finasteride Syndrome: An Underestimated Phenomenon: Urology and Andrology, September 2016. [Propecia] has the sexual side effects, like erectile dysfunction, which can affect men for years. What do you think about a PCT strategy to see if that helps? Hi, being a young guy with PFS since 8 months this article has been very helpful to furthermore understand what is possibly going on, so thank you. Men who take finasteride for baldness or receding hairlines can develop sexual dysfunction. We recommend patients who have already submitted a report submit a new one using this reaction type. Post-finasteride syndrome is leaving behind a slew of victims in its trail. However, studies have documented depression and anxiety among finasteride patients, along with sexual side effects, and symptoms can persist for months or years after stopping the drug. Good hypothesis! You may instead use topical minoxidil (Rogaine), which has no known negative effects on male fertility. Long-term-treatment follow-up revealed that (5 mg/day) effects on hair growth are sustained in most women. Discontinuation of the drug should actually make the hormones work again.but apparently, something breaks down in some men, in the prostate, in the brain, in the whole organism. What is post-fin syndrome anyway? My biggest issue is low/no libido. [A]pproximately 30 million young men, worldwide, would be prescribed finasteride or dutasteride to treat male pattern hair loss. : June 21, 2022. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma: Journal of Steroid Biochemistry and Molecular Biology, February 2015. Documentary on German network NDR titled Side Effects of Finasteride Are Underestimated: January 25, 2021. I took and i am taking many of the supplements listed with no real improvements. Im not beholden to trT. 5-reduced steroids are significantly increased in a hyperthyroid state. Our analysis indicates that, nonetheless, [PFS] is clearly a problem that is important to the general public that warrants intervention. If you are unable to import citations, please contact Both are inconsistent. cold penis Re: Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians. Topical TRT will increase DHT even more. [F]inasteride is associated with common adverse health effects in women with long-term treatment for androgenetic alopecia, such as irregular menstrual cycle, aromatase disorder, high cholesterol, heavy menstrual bleeding and induced DNA damage. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. You dont have to be a genius to realize that, when youre taking away the most potent form of testosterone, and youre affecting, for example, ejaculate volume, clearly something is changing around the prostate area. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women: Bioscience Reports, February 2020. I have had retraction of penis and man boobs. There is accumulating evidence that it negatively impacts male fertility. Optimize thyroid. Use Catuaba bark extract, mucuna pruriens, Tribulus Terrestris, etc. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens, Psychoneuroendocrinology, October 2016. I will start Progesterone cream with tongkat ali soon. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Some people actually report dramatic improvements in their symptoms after starting a certain SSRI. A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Responding, via Twitter, to the study Association of 5-Reductase Inhibitors With Dementia, Depression, and Suicide: December 24, 2022. In this episode, Dr. Vikram Jayaprakash and Dr. Russell Knudsen discuss the concept of post-finasteride syndrome. Taking Propecia or Proscar to Prevent Hair Loss is Associated with Depression, Anxiety, and Sexual Problems: National Center for Health Research website, 2021. Mens Health and Fertility Lifestyle Information: Weill Cornell Medicine Center. I think we need to put the [PCPT] trial concerns to rest. The Food and Drug Administration Adverse Event Reporting System (FAERS) was queried to identify medications with the highest frequency of ED adverse event reports from 2010-2020 The top 20 medications with the highest frequency of ED were included in the disproportionality analysis Of these 20 medications, there were 6,142 reports of ED and 5-alpha reductase inhibitors (5-ARIs) accounted for 2,823 (46%) of these reports Seven medications showed significant levels of disproportionate reporting but finasteride and dutasteride had the highest PRRs: 110.03 (103.14-117.39) and 9.40 (7.83-11.05) respectively Physicians and patients should be familiar with medications that are associated with ED. Suicidality and Psychological Adverse Events in Patients Treated with Finasteride. Statement via Twitter to fellow clinicians: June 5, 2022. is a recovery really possible? Reaction (via Twitter) to publication of the study Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, in JAMA Dermatology, January 19, 2021. I just picked up Gaba, im assuming this is a good idea? I want to try a combination of what you have listed above mainly to try and increase dopamine. A pharmacogenetic survey of androgen receptor (CAG)n and (GGN)n polymorphisms in patients experiencing long term side effects after finasteride discontinuation: International Journal of Biological Markers, Dec. 9, 2014. Increasing carbon dioxide production. It's sold under the brand names Propecia and Proscar. A Comment on the Post-Finasteride Syndrome. Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model. CreGAAtine vs creatine monohydrate: Its not better! This research should cause us to think more carefully about this commonly encountered medication. I wanted to take a minute to talk to you about post-finasteride syndrome since more and more men are coming in with complaints after taking finasteride. So thats all gone in many men, just because of finasteride. Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. I train a lot, heavy resistance, HIIT, play sport, drink very little. You definitely want high dopamine and low serotonin to optimize cognition and mindset. Stop finasteride: 45.6% Health Canada recently recommended adding a warning to products containing [finasteride] While being administered the above-mentioned drug, patients may develop muscle weakness and stiffness, which in turn may cause pain to the patient, damage to muscle tissue and an increase in kinase enzymes. But Nobody Warned Me about Finasteride! It scrambles your hormones, libido and cognition all over the place, right into the gutters, and leaves you feeling like an empty dysfunctional husk. Some have petitioned the FDA to include post-finasteride syndrome as a boxed warning. This is the most serious warning given about a medication. It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. Acufene And I have to use huge amounts of testosterone to overcome this drug. Bethesda, MD 20894, Web Policies Meanwhile, professional organizations may provide educational materials for physicians in order to increase their awareness regarding the scope of these persistent catastrophic adverse effects of finasteride and dutasteride. Even if you take just a little finasteride, it can actually drop your DHT so low that men become impotent. If you know of additional doctors, researchers and/or therapists who have published warnings of persistent side effects stemming from finasteride use, and/or if you would like to suggest adding a medical professional to our Medical Professionals list, please email pertinent links/names to proberts@pfsfoundation.org. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia: Translational Andrology and Urology, April 2020. Patients should be informed of these risks, so that they can weigh the benefits of harms against treatment. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Finasteride inhibits Type II 5(alpha)-reductase, which metabolizes testosterone to the potent androgen 5(alpha)-dihydrotestosterone. Before This may result in side effects such as memory problems or sexual dysfunction (problems that affect the desire for or ability to have sex). [T]here has been a Red Hand Letter for this drug since 2018. Emerging post-marketing reports of persistent depression and sexual side effects have led to growing concerns about the safety of 5-reductase inhibitors and prompted product labeling changes in many regulatory jurisdictions. These drugs are poison. Bethesda, MD 20894, Web Policies As yet, the condition is not recognized by the medical community, although individuals who suffer from PFS present with relatively homogenous symptoms. Only individuals who are born with intersex characteristics (hermaphrodites) have low levels of this hormone. That may [be] very harmful for the users. Find support. Concern regarding adverse effects of finasteride is increasing. PFS can start shortly after starting the medication and can possibly last months to years after stopping. Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? Statement (via Twitter) in response to a study titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, December 7, 2020. Would you like email updates of new search results? PMC Proscar can hardly be categorized as safe because it can cause breast augmentation, reduced libido andimpotence. Sexual, physical, and overall adverse effects in patients treated with 5-reductase inhibitors: a systematic review and meta-analysis. But I am actually not interested in you. Response via Twitter to the Karolinska Institutet study Association of 5-Reductase Inhibitors With Prostate Cancer Mortality: May 31, 2022.

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